Protein Details: Voltage-gated Potassium channel-interacting protein 1

Protein ID

ICDB_Pro_1593

Protein Name

Voltage-gated Potassium channel-interacting protein 1

Gene Name

KCNIP1; KCHIP1; VABP

Organism

Homo sapiens (Human)

Length

227 amino acids

AlphaFoldDB

AF-Q9NZI2-F1-model_v4.pdb

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density;inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro;modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface

Sequence

MGAVMGTFSSLQTKQRRPSKDIAWWYYQYQRDKIEDELEMTMVCHRPEGLEQLEAQTNFTKRELQVLYRGFKNECPSGVVNEDTFKQIYAQFFPHGDASTYAHYLFNAFDTTQTGSVKFEDFVTALSILLRGTVHEKLRWTFNLYDINKDGYINKEEMMDIVKAIYDMMGKYTYPVLKEDTPRQHVDVFFQKMDKNKDGIVTLDEFLESCQEDDNIMRSLQLFQNVM

PDB Structures

1S1E 2I2R 2NZ0 7E83 7E84 7F3F 7W6N 7W6T

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

146;148;150;152;157;194;196;198;205

Disease

Epilepsy;Idiopathic Generalized and Hypertension;Diastolic

Location

Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform 1 is also expressed in liver; pancreas; skeletal muscle; small intestine and testis. Isoform 2 is also expressed in lung; pancreas; leukocytes; prostate and thymus.

DOI ID

10.1038/35000592; 10.1016/j.ygeno.2005.07.001; 10.1038/ng1285; 10.1038/nature02919; 10.1101/gr.2596504; 10.1016/s1044-7431(03)00174-x; 10.1016/s0014-5793(01)02560-1; 10.1074/jbc.m306142200; 10.1016/j.bbrc.2004.05.064; 10.1016/j.bbrc.2004.07.006; 10.1016/s0896-6273(04)00049-2; 10.1038/nsmb1164; 10.1038/nn1822

RefSeq

NP_001030009.1 [Q9NZI2-1]; NP_001030010.1 [Q9NZI2-4]; NP_001265268.1 [Q9NZI2-5]; NP_001265269.1 [Q9NZI2-3]; NP_055407.1 [Q9NZI2-2]; XP_016864896.1 [Q9NZI2-4]